Cinnamaldehyde Relieves Induced Hepatocellular Carcinoma in Rat Model via Targeting Wnt/?-Catenin Pathway

Cinnamaldehyde (CA) is a natural compound that has promising biological activity. The current study investigates the antitumor activity of CA in thioacetamide induced hepatocellular carcinoma (HCC) rats through targeting Wnt/?-catenin pathway and evaluates capability to relieve hepatocytes oxidative stress HCC-rat model. After 16 weeks HCC induction by (TAA), were treated for 7 consecutive with daily; i.p. injection, Alpha-fetoprotein (AFP) level, necroinflammatory score fibrosis percentage measured assess development. was evaluated measuring hepatic protein level Wnt-3a, ?-catenin, cyclin D, matrix metalloproteinase-9 (MMP-9), vascular endothelial growth factor (VEGF). Furthermore, hepatocytes’ assessed GSH MDA contents. Results showed significantly inhibiting downregulation MMP-9, VEGF. Moreover, ameliorates via lowering content rising content. Thus, conclusion, treatment HCC. It not only an effective but also stress.